NOVEL THERAPEUTIC AGENTS THAT MODULATE ESTROGEN RECEPTORS
摘要
Disclosed are novel multi-binding compounds (agents) which bind estrogen receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the estrogen receptors.
申请公布号
WO9963944(A3)
申请公布日期
2000.02.10
申请号
WO1999US12995
申请日期
1999.06.08
申请人
ADVANCED MEDICINE, INC.;MORAN, EDMUND, J.;NUMEROF, ROBERT, P.;GRIFFIN, JOHN, H.
发明人
MORAN, EDMUND, J.;NUMEROF, ROBERT, P.;GRIFFIN, JOHN, H.