OPTICAL IN VIVO ANALYTE PROBE USING EMBEDDED INTRADERMAL PARTICLES

摘要

A system and method of in vivo detection and quantification of one or more analytes. Small particles comprising a surface-active monolayer coating are embedded in the dermis. The surface-active monolayer acts to pre-concentrate the analyte by adsorbing the analyte from bulk solution. The concentrated analyte is more readily detected and quantified by one or more spectroscopic methods such as Raman spectroscopy.