GEOMETRICALLY RESTRICTED 3-CYCLOPENTYLIDENE-1,3-DIHYDROINDOL-2-ONES AS POTENT PROTEIN KINASE INHIBITORS
摘要
The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula (I): wherein R1 - R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
申请公布号
WO2005016875(A2)
申请公布日期
2005.02.24
申请号
WO2004US22310
申请日期
2004.08.05
申请人
SUGEN, INC.;ZHANG, FANG-JIE;CUI, JINGRONG;WEI, CHUNG, CHEN;TANG, PENG, CHO
发明人
ZHANG, FANG-JIE;CUI, JINGRONG;WEI, CHUNG, CHEN;TANG, PENG, CHO