The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the VH and VL sequences of the reference antibody with sequences from human antibody repertoires. The invention also provides novel compositions comprising hybrid immunoglobulin variable domains containing a combination of frameworks (FRs) and CDRs from different antibody clones.
申请公布号
WO2006055778(A2)
申请公布日期
2006.05.26
申请号
WO2005US41825
申请日期
2005.11.16
申请人
KALOBIOS, INC.;BEBBINGTON, CHRISTOPHER R.;LUEHRSEN, KENNETH R.;YARRANTON, GEOFFREY T.
发明人
BEBBINGTON, CHRISTOPHER R.;LUEHRSEN, KENNETH R.;YARRANTON, GEOFFREY T.