ANTIBODIES BINDING TO RECEPTORS KIR2DL1, -2, 3 BUT NOT KIR2DS4 AND THEIR THERAPEUTIC USE

摘要

Compositions and methods for regulating an immune response in a subject are de­scribed. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1­4F1. Described also are also fragments and derivatives of such antibodies, as well as phar­maceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.