发明名称 |
Radiolabelled phenylethyl imidazole carboxylic acid ester derivatives |
摘要 |
Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrate a selective and high rate of accumulation in the adrenals. The method of preparing these derivatives proceeds by the conversion of a stable, non-radioactive intermediate having trialkylstannyl leaving groups. These intermediates are efficiently converted to the corresponding halogenated forms by substitution of the trialkylstannyl group with the halogen or radiohalogen.
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申请公布号 |
US7358369(B2) |
申请公布日期 |
2008.04.15 |
申请号 |
US20060582073 |
申请日期 |
2006.10.17 |
申请人 |
ZOLLE ILSE;HAMMERSCHMIDT FRIEDRICH |
发明人 |
ZOLLE ILSE;HAMMERSCHMIDT FRIEDRICH |
分类号 |
C07D233/54;A61K31/4164;C07D233/64;C07D233/90 |
主分类号 |
C07D233/54 |
代理机构 |
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