| 发明名称 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases | ||
| 摘要 | Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | ||
| 申请公布号 | US9347053(B2) | 申请公布日期 | 2016.05.24 |
| 申请号 | US201514689900 | 申请日期 | 2015.04.17 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain P.;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
| 分类号 | C07K16/40;G01N33/573;C12N9/00;A61K38/00 | 主分类号 | C07K16/40 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. A pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a modified mRNA polynucleotide that encodes an isolated glutaminyl-tRNA synthetase (GInRS) polypeptide of up to 200 amino acids in length and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 209 or 237, wherein the GInRS polypeptide has an extracellular signaling activity, and wherein the composition is substantially endotoxin-free. | ||
| 地址 | San Diego CA US | ||