发明名称 | Trifluoroborate mass spectrometric tags | ||
摘要 | The invention provides compositions and methods for mass spectrometric (MS), organic synthesis, and applications of organo-trifluoroborate, for example, as mass tags for use in negative ion mode. When subject to MS fragmentation, organo-trifluoroborates preferentially undergo neutral losses of hydrogen fluoride (HF) or boron trifluoride (BF3) molecules, transferring the negative charge to the rest of the molecule. Such a fragmentation pattern is used to detect and quantitate analytes of interest after derivatization with organo-trifluoroborates. | ||
申请公布号 | US9346833(B2) | 申请公布日期 | 2016.05.24 |
申请号 | US201414779805 | 申请日期 | 2014.03.26 |
申请人 | CellMosaic, Inc. | 发明人 | Huang Yumei |
分类号 | H01J49/40;C07F5/02;C08G65/34;H01J49/00 | 主分类号 | H01J49/40 |
代理机构 | Milstein Zhang & Wu LLC | 代理人 | Milstein Zhang & Wu LLC |
主权项 | 1. A method for mass spectrometric analysis, comprising fragmenting organo-trifluoroborate or an analyte tagged with one or more organo-trifluoroborate mass tags comprising one or more trifluoroborate groups in negative ion mode to produce one or more negatively charged fragment ions and one or more molecules with no charge. | ||
地址 | Woburn MA US |