Substituted 7-oxo-pyrido[2,3-d]pyrimidines and methods of use

摘要

The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer.

主权项

1. A compound of Formula I wherein R1 is wherein Ring A is 5 membered heteroaryl; wherein Ring T is phenyl or 6 membered heteroaryl; wherein R2 is H, F, Cl or methyl; wherein R3 is H, C1-C6 alkyl or C1-C6 dialkylamino-C1-C6 alkyl; wherein R5 is unsubstituted or substituted 5-6 membered saturated heterocyclyl or substituted 4-7 membered heterocyclylamino; wherein R6 is H, C1-C6 alkoxy, C1-C6 haloalkoxy or halo; and wherein X is CH or N; provided R5 is not 4-morpholinyl; and pharmaceutically acceptable salts thereof.