Polyamine transport selective therapeutic agents with enhanced stability

摘要

Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.

主权项

1. A compound of the following the formula:
R′HN—(CH2)x—NH—(CH2)y—NH—CH2—R—CH2—NH—(CH2)xx—NH—(CH2)yy—NHR″  (I) wherein R is selected from the group consisting of anthracene, naphthalene, and benzene; wherein x, xx, y, and yy are independently selected from the group consisting of 3 and 4; or a pharmaceutically acceptable salt thereof; wherein R′ and R″ are independently selected from the group consisting of methyl, ethyl, propyl, isopropyl, and butyl.