Protein disulfide isomerase assay method for the in vitro diagnosis of colorectal cancer

摘要

A method for the in vitro diagnosis of colorectal cancer that comprises determining the presence of the protein disulfide isomerase tumor marker in a biological sample taken from a patient suspected of having colorectal cancer using at least one anti-PDI monoclonal antibody directed against a PDI epitope chosen from the epitopes of sequence SEQ ID No.1, SEQ ID No.2, with an aromatic amino acid which is close in the three-dimensional structure of PDI and SEQ ID No.3.

主权项

1. An isolated peptide comprising the amino acid sequence of SEQ ID NO:3, wherein the peptide has from 1 to 6 additional amino acid residues on at least one side of the amino acid sequence of SEQ ID NO:3 that are different from the corresponding amino acid residues of the protein disulfide isomerase (PDI) amino acid sequence.