发明名称 |
T CELL RECEPTORS THAT ARE SPECIFIC TO A FLUORESCENT PROTEIN, TRANSGENIC ANIMALS AND METHODS OF THEIR MAKING, ISOLATED T CELLS, AND METHODS OF USE |
摘要 |
This invention relates to a transgenic non-human mammal whose genome comprises a polynucleotide sequence encoding a T cell receptor that is specific to a fluorescent protein, where the T cell of the non-human mammal comprises the T cell receptor. The present invention also relates to an isolated T cell from the transgenic non-human mammal of the present invention, an isolated T cell comprising an expression construct comprising a polynucleotide sequence that encodes a T cell receptor that is specific to a fluorescent protein, methods of making transgenic non-human mammals comprising T cell receptors that are specific to a fluorescent protein, a method of depleting cells in a non-human mammal using isolated T cells that encode a T cell receptor that is specific to a target protein, and a method of characterizing a T cell response to an agent. |
申请公布号 |
US2016219844(A1) |
申请公布日期 |
2016.08.04 |
申请号 |
US201415021026 |
申请日期 |
2014.09.12 |
申请人 |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
BROWN Brian;AGUDO Judith |
分类号 |
A01K67/027;G01N33/566;C07K14/725 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A transgenic non-human mammal whose genome comprises a polynucleotide sequence encoding a T cell receptor that is specific to a fluorescent protein, wherein a T cell of the non-human mammal comprises the T cell receptor. |
地址 |
New York NY US |