| 发明名称 | Microorganisms for therapy | ||
| 摘要 | Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided. | ||
| 申请公布号 | US9492534(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414301813 | 申请日期 | 2014.06.11 |
| 申请人 | Genelux Corporation | 发明人 | Szalay Aladar A.;Timiryasova Tatyana;Yu Yong A.;Zhang Qian |
| 分类号 | A61K39/285;A61K35/768;C12P19/34;A61K35/744;C12P21/02;C12N7/00;C07K16/40;A61K35/74;C07K16/30;C12N15/86;A61K39/00;A61K48/00 | 主分类号 | A61K39/285 |
| 代理机构 | Dentons US LLP | 代理人 | Dentons US LLP ;Seidman Stephanie |
| 主权项 | 1. An isolated cell, comprising a recombinant vaccinia virus that comprises a modified thymidine kinase (TK) gene and a modified hemagglutinin (HA) gene, and an insertion, deletion or mutation in the gene or locus designated F3, wherein: each of the TK, HA and F3 gene or locus is inactivated; and the F3 locus occurs on the HindIII-F fragment of the vaccinia virus between open reading frames F14L and F15L. | ||
| 地址 | San Diego CA US | ||