Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use

摘要

Chimeric fHBPs that can elicit antibodies that are bactericidal for different fHBP variant strains of N. meningitidis, and methods of use, are provided.

主权项

1. A chimeric factor H binding protein (fHBP) comprising,
contiguously from its N-terminus to C-terminus:
a first amino acid sequence at least 90% identical to the contiguous amino acid sequence of SEQ ID NO: 4 from residue 94 to residue 128;a GEHT (SEQ ID NO: 7) sequence; anda second amino acid sequence at least 90% identical to the contiguous amino acid sequence of SEQ ID NO: 1 from residue 133 to residue 247;wherein the chimeric fHBP comprises an epitope bound by JAR5 monoclonal antibody and an epitope bound by a monoclonal antibody specific for an epitope of v. 2 or v. 3 fHBP of a Neisseria meningitidis strain.