Apparatus for the controlled release of topical nitric oxide

摘要

A stable delivery system for the therapeutic release and application of nitric oxide to a patient suffering from a cutaneous injury or wound includes a S-nitrosothiol and transition element nanoparticles. The transition metal nanoparticles are selected to react with the S-nitrosothiol to release and diffuse nitric oxide into the injury or wound.

主权项

1. A cutaneous injury treatment system comprising:
a storage reservoir containing a volume of S-nitrosothiol; a reactive medium comprising a transition metal component reactable with said S-nitrosothiol to release a therapeutically effective amount of nitric oxide, the reactive medium being selected from the group consisting of a polydimethylsiloxane nanocomposite, a glass nanocomposite impregnated with at least one of gold nanoparticles, silver nanoparticles and copper nanoparticles, and a cotton gauze substrate impregnated with at least one of gold nanoparticles, silver nanoparticles and copper nanoparticles, a storage barrier for maintaining said volume of S-nitrosothiol in said reservoir physically separate from said reactive medium during storage or transport of said cutaneous injury treatment system; and wherein said system is selectively activatable to effect the mixture of at least part of said volume of S-nitrosothiol and said reactive medium to release said amount of nitric oxide.