MODULATION OF GROWTH HORMONE RECEPTOR EXPRESSION AND INSULIN-LIKE GROWTH FACTOR EXPRESSION
摘要
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
申请公布号
WO2004078922(A3)
申请公布日期
2006.12.21
申请号
WO2004US05896
申请日期
2004.02.27
申请人
ISIS PHARMACEUTICALS, INC.;TACHAS, GEORGE;DOBIE, KENNETH;JAIN, RAVI;BELYEA, CHRISTOPHER;HEFFERNAN, MARK
发明人
TACHAS, GEORGE;DOBIE, KENNETH;JAIN, RAVI;BELYEA, CHRISTOPHER;HEFFERNAN, MARK