METHODS AND INTERMEDIATES FOR SYNTHESIS OF SELECTIVE DPP-IV INHIBITORS
摘要
Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.
申请公布号
WO2008109681(A2)
申请公布日期
2008.09.12
申请号
WO2008US55927
申请日期
2008.03.05
申请人
PHENOMIX CORPORATION;CAMPBELL, DAVID ALAN;LEITAO, EMILIA P.T.;WU, ZHEN-PING;WANG, PENG
发明人
CAMPBELL, DAVID ALAN;LEITAO, EMILIA P.T.;WU, ZHEN-PING;WANG, PENG