| 发明名称 | Polymorphic forms of naltrexone | ||
| 摘要 | This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations. | ||
| 申请公布号 | US9365580(B2) | 申请公布日期 | 2016.06.14 |
| 申请号 | US201514945607 | 申请日期 | 2015.11.19 |
| 申请人 | Alkermes Pharma Ireland Limited | 发明人 | Brittain Harry G.;Dickason David A.;Hotz Joyce M.;Lyons Shawn L.;Ramstack J. Michael;Wright Steven G. |
| 分类号 | A61K31/485;C07D489/08;C07C19/03 | 主分类号 | A61K31/485 |
| 代理机构 | Elmore Patent Law Group, P.C. | 代理人 | Elmore Patent Law Group, P.C. ;Harlan Edgar W.;Elmore Carolyn S. |
| 主权项 | 1. A polymorphic form of naltrexone methanol solvate which is characterized by at least one of: (a) the X-ray powder diffraction pattern of FIG. 4A; (b) the differential scanning calorimetry thermogram of FIG. 16A; and (c) the IR-ATR spectrum of FIG. 28A. | ||
| 地址 | Dublin IE | ||