| 主权项 |
1. A compound of the formula (II):wherein:
R3 is selected from the group consisting of
—Z—Y3—R4-3,—Z—Y3—X3—Y3—R4-3,—Z-Het,—Z-Het′-R4, and—Z-Het′-Y—R4; Z is selected from the group consisting of alkylene, alkenylene, and alkynylene, wherein alkylene, alkenylene, and alkynylene can be optionally interrupted with one or more —O— groups; Y3 is selected from the group consisting of:
—S(O)0-2—,—C(R6)—,—C(R6)—O—,—O—C(R6)—, and—O—C(O)—O—; R is selected from the group consisting of alkyl, alkoxy, hydroxy, halogen, and trifluoromethyl; n is 0 or 1; R1 is selected from the group consisting of alkyl, alkoxyalkylenyl, aminoalkylenyl, hydroxyalkylenyl, dihydroxyalkylenyl and alkyl substituted by a group selected from the group consisting of —NH—C(O)-alkyl, —NH—S(O)2-alkyl, —NH—C(O)—NH-alkyl, —NH—C(O)—O-alkyl, phenoxy, tetrahydropyranyl, 1,1-dioxidoisothiazolidin-2-yl, and 2,2-dimethyl-1,3-dioxolan-4-yl; R2 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and hydroxyalkylenyl; X3 is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, heteroarylene, and heterocyclylene wherein the alkylene, alkenylene, and alkynylene groups can be optionally interrupted or terminated with arylene, heteroarylene, or heterocyclylene, and optionally interrupted by one or more —O— groups, wherein heterocyclylene is non-aromatic and contains at least one ring heteroatom, wherein the at least one ring heteroatom is selected from the group consisting of an oxygen atom and a sulfur atom; Y is selected from the group consisting of
—S(O)0-2—,—S(O)2—N(R8)—,—C(R6)—,—C(R6)—O—,—O—C(R6)—,—O—C(O)—O—,—N(R8)-Q-,—C(R6)—N(R8)—,—O—C(R6)—N(R8)—,—C(R6)—N(OR9)—, R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo; R4-3 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo, wherein heterocyclyl is non-aromatic and contains at least one ring heteroatom, and wherein the at least one ring heteroatom is selected from the group consisting of an oxygen atom and a sulfur atom; R6 is selected from the group consisting of ═O and ═S; R7 is C2-7 alkylene; R8 is selected from the group consisting of hydrogen, alkyl, alkoxyalkylenyl, and arylalkylenyl; R9 is selected from the group consisting of hydrogen and alkyl; R10 is C3-8 alkylene; Het is a non-aromatic heterocyclyl that contains at least one ring heteroatom, wherein the at least one ring heteroatom is selected from the group consisting of an oxygen atom and a sulfur atom, and wherein the non-aromatic heterocyclyl can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, aryloxy, arylalkyleneoxy, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, hydroxyalkyleneoxyalkylenyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and oxo; Het′ is a non-aromatic heterocyclylene that contains at least one ring heteroatom, wherein the at least one ring heteroatom is selected from the group consisting of an oxygen atom and a sulfur atom, and wherein the non-aromatic heterocyclyl can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, hydroxyalkyl, mercapto, cyano, aryloxy, arylalkyleneoxy, heteroaryloxy, heteroarylalkyleneoxy, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and oxo; Q is selected from the group consisting of a bond, —C(R6)—, —C(R6)—C(R6)—, —S(O)2—, —C(R6)—N(R8)—W—, —S(O)2—N(R8)—, —C(R6)—O—, and —C(R6)—N(OR9)—; V is selected from the group consisting of —C(R6)—, —O—C(R6)—, —N(R8)—C(R6)—, and —S(O)2—; W is selected from the group consisting of a bond, —C(O)—, and —S(O)2—; and with the proviso that Z can also be a bond when:
R3 is —Z-Het, —Z-Het′-R4, or —Z-Het′-Y—R4; orR3 is —Z—Y3—R4 or —Z—Y3—X—Y3—R4, and Y3 is selected from —S(O)0-2—, —C(R6)—, and —C(R6)—O—;or a pharmaceutically acceptable salt thereof. |
