发明名称 |
TREATMENT OF PYRROLINE-5-CARBOXYLATE REDUCTASE 1 (PYCR1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PYCR1 |
摘要 |
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1. |
申请公布号 |
EP2539452(B1) |
申请公布日期 |
2016.07.27 |
申请号 |
EP20110745402 |
申请日期 |
2011.02.21 |
申请人 |
CURNA, INC. |
发明人 |
COLLARD, JOSEPH;KHORKOVA SHERMAN, OLGA |
分类号 |
C12N15/113;A61K31/7088;A61K48/00;A61P3/00;C12N15/63 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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