Sustained-release composition containing peptides as active ingredient

摘要

The present invention relates to a sustained-release drug composition consisting essentially of microparticles of a peptide as the active substance and a biocompatible water-soluble polymer, in particular peptide as meianocortin receptor ligand. The present invention relates also to an injection formulation comprising the sustained-release drug composition suspended in an injection medium.

主权项

1. A sustained-release drug composition comprising microparticles comprising:
a peptide of formula (I),
Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2  (I), or a pharmaceutically-acceptable salt thereof; and a biocompatible water-soluble polymer; wherein the peptide and the biocompatible water-soluble polymer are at least 90% by weight of the microparticles and the peptide is present at a concentration of from about 20% to about 70% by weight of the microparticles.