发明名称 Use of metallocene compounds for cancer treatment
摘要 Metallocene compounds and pharmaceutical compositions containing these metallocene compounds are disclosed and described. Methods of treating cancer employing such metallocene compounds and pharmaceutical compositions also are provided.
申请公布号 US9441000(B2) 申请公布日期 2016.09.13
申请号 US201414327647 申请日期 2014.07.10
申请人 Chevron Philips Chemical Company, LP 发明人 Hlavinka Mark L.;Yang Qing;Murph Mandi Michelle
分类号 A61K31/28;A61K31/695;C07F7/28;A61K38/21;A61K45/06;A61K31/135;A61K31/337;A61K31/415;A61K31/513;A61K31/7068;A61K31/7135;C07F7/00;C07F7/02 主分类号 A61K31/28
代理机构 Merchant & Gould P.C. 代理人 Merchant & Gould P.C.
主权项 1. A pharmaceutical composition comprising: a therapeutically effective amount of a metallocene compound having formula MET-B, or a pharmaceutically acceptable salt thereof:  and a pharmaceutically acceptable diluent, excipient, or carrier; wherein: M is Ti, Zr, or Hf; each Rx, RY, and Rz independently is H, a halide, hydrocarbyl group, halogenated hydrocarbyl group, oxygen-containing group, sulfur-containing group, nitrogen-containing group, or silicon-containing group; E1 is C or Si; R1 and R2 are independently H or a hydrocarbyl group, halogenated hydrocarbyl group, oxygen-containing group, sulfur-containing group, nitrogen-containing group, or silicon-containing group; X1 and X2 are independently a monoanionic ligand; and q, r, and s are independently 0, 1, 2, 3, or 4.
地址 The Woodlands TX US