Tricyclic derivatives of N,N′-substituted 3,7-diazabicyclo [3.3.1]nonanes and drugs based thereon

摘要

The invention relates to novel 3,6,9-triazatricyclo[7.3.1.1]tetradecane-4,8,12-trione derivatives of general formula (1), which act as allosteric AMPA receptor modulators, and to drugs based thereon which can be used for treating Alzheimer's, Parkinson's and other neurodegenerative diseases.;

主权项

1. A pharmaceutical composition, the composition comprising a compound of a general formula 1, or a pharmacologically acceptable acid or salt thereof: wherein:
X is a carbonyl group, or a methylene bridge;R1 and R′1 are identical or different, and each independently is H, C1-C6 alkyl, or C1-C10 alkoxy;R2 is selected from the group consisting of general formulae (1.1a), (1.2a), (1.3a), and (1.4a): R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, R′9, R10, R′10, R11, R′11, R15 and R′15 are identical or different, and each independently is H, C1-C6 alkyl, or C1-C10 alkoxy;R12 is C1-C6alkyl;R13 and R13′ are identical or different, and each independently is H, C1-C6 alkyl, C1-C10 alkoxy, hydroxy, halogen, amino, nitro group, nitrile, acyl, or aryl;Z is N or CH;E is N, or a group having a general formula: wherein: n equals 1, 2, or 3;
R14 is H, C1-C6 alkyl, C1-C10 alkoxy, or hydroxyl;Y is —(CR16R′16)m—, wherein m equals 1, 2, or 3;R16 and R′16 are identical or different, and each independently is H, C1-C6 alkyl, or C1-C10 alkoxy.