INHIBITOR TARGETING SPECIFIC COMPLEMENT SYSTEM, AND PREPARATION METHOD AND USE THEREOF

摘要

An inhibitor targeting specific complement, the inhibitor targeting specific complement is a protein, the protein has a targeted inhibition function on the complement activation, and the amino acid sequence of the protein comprises CRIg extracellular domain and complement inhibiting domain; the amino acid sequence of the protein is consist of the CRIg extracellular domain and the complement inhibiting domain connected directly, or indirectly through a linker which can connect the two domains The preparation method of the inhibitor targeting specific complement comprises connecting the protein polypeptides of the CRIg extracellular domain and the complement inhibiting domain by gene engineering technology. The protein can be used to prepare a drug targeting inhibition of complement activation. The inhibitor targeting specific complement, its preparation method and applications provided by the present invention, can be used in the treatment and prevention of human diseases caused by complement activation disorders. It has great potential application value and development prospects.

主权项

1. An inhibitor protein targeting specific complement, having a targeted inhibition function against complement activation, comprising:
a CRIg extracellular domain amino acid sequence portion; and a complement inhibiting domain amino acid sequence portion connected to the CRIg extracellular domain amino acid sequence portion, selected from the group consisting of:
factor HC1 inhibiting protein,C4 binding protein,factor IS protein,clusterin,at least one of complement membrane regulatory protein CD35/CR1, CD46/MCP, CD55/DAF, and CD59,a functional fragment of CRIg, anda full-length CRIg.