TIMP3 as VEGF inhibitor

摘要

Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (TIMP3) or variants of TIMP3 can be used to substantially inhibit vascular endothelial growth factor (VEGF) binding to VEGF receptor-2 (VEGFR2/KDR/Flk-1)) without substantially inhibiting VEGF binding to VEGF receptor 1 (VEGFR1/Flt-1).

主权项

1. A method of inhibiting VEGF induced endothelial cell proliferation and/or migration in a population of VEGFR2 expressing endothelial cells in the presence of VEGF, the method comprising:
administering to the VEGFR2 expressing endothelial cells a polypeptide comprising a fragment of TIMP3 that includes SEQ ID NO: 9, wherein the polypeptide is effective to inhibit endothelial cell proliferation and/or migration in the population of VEGFR2 expressing endothelial cells and wherein the polypeptide is free of metalloproteinase inhibiting activity.