摘要 |
<p>4-Arylmethylene-1,4-dihydro-2H-azine derivatives represented by general formula (1), geometric isomers thereof, or pharmaceutically acceptable salts of the same, which are useful as osteoclast differential induction inhibitors, antiinflammatory agents, osteoclasis inhibitors, antirheumatic agents, etc. In said formula Ar represents optionally substituted aryl or optionally substituted heteroaryl; the ring Ar1 represents an optionally substituted aromatic hydrocarbon ring or optionally substituted heteroaryl; R1 represents hydrogen, optionally substituted carbamoyl, optionally substituted sulfamoyl, etc.; R2 represents hydrogen, optionally substituted carbamoyl, optionally substituted sulfamoyl, etc.; E represents oxygen, sulfur or -N(R8)-; and A represents oxygen, sulfur or -N(R12)-.</p> |