POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS AS REGULATORY SWITCHES

摘要

The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and the carboxy terminus of the H2A and H2B peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-translational modifications of histone proteins that function as switches for regulating transcription and mitosis. Compositions comprising these antibodies are used as diagnostic and screening tools.