发明名称 |
Methods of treating allergic inflammatory conditions by administering an anti-cadherin-like 26-based therapeutic |
摘要 |
Embodiments of the invention are directed to methods of diagnosing eosinophilic gastritis (EG), or remission therefrom in a subject, wherein the methods include applying a sample from the subject to a diagnostic panel that contains selected markers for EG, analyzing the results thereof, and making a determination as to the EG status of the subject. Embodiments of the invention are also directed to methods of monitoring the pathological development or medical prognosis of EG in a subject. Embodiments of the invention are also directed to use of CDH26 as a marker for EG, eosinophilic esophagitis, or allergic inflammatory conditions. Embodiments of the invention also relate to the use of anti-CDH26-based therapeutics to treat allergic inflammatory conditions. |
申请公布号 |
US9345763(B2) |
申请公布日期 |
2016.05.24 |
申请号 |
US201214128887 |
申请日期 |
2012.06.25 |
申请人 |
Children's Hospital Medical Center |
发明人 |
Rothenberg Marc E.;Caldwell Julie |
分类号 |
A61K31/7088;A61K31/713;A61K39/395;A61K48/00;C07K16/18;C12N15/11;C12N15/113;C12Q1/68;G01N33/68 |
主分类号 |
A61K31/7088 |
代理机构 |
Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. |
代理人 |
Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Liberto, Esq. Muriel |
主权项 |
1. A method of treating an allergic inflammatory condition in a subject in need thereof, comprising administering to the subject an amount of an anti-cadherin-like 26 (CDH26)-based therapeutic effective to suppress CDH26, thereby treating the allergic inflammatory condition in the subject. |
地址 |
Cincinnati OH US |