Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury

摘要

The invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods provide administering aromatic-cationic peptides in effective amounts to prevent or treat an anatomic zone of no re-flow in mammalian subjects. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

主权项

1. A method for treating a anatomic zone of no re-flow in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a peptide D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof, thereby treating the anatomical zone of no re-flow in the subject, wherein the anatomic zone of no re-flow comprises a zone of persistent ischemia.