| 主权项 |
1. A method of treating acute heart failure, comprising administering to a patient in need thereof an effective amount of a compound of the formula or a pharmaceutically acceptable salt thereof, wherein q is 0, 1, or 2; s is 0, 1, or 2; R3, each time taken, is independently selected from the group consisting of hydrogen, hydroxyl, amino, C1-8 alkylamino, cyano, halo, C1-6 alkyl, and C1-4 alkoxy; R4 is selected from the group consisting of hydrogen, cyano, halo, methyl, ethyl, methoxy, and trifluoromethyl; R5 is selected from the group consisting of R6, each time taken, is independently selected from the group consisting of hydrogen, cyano, halo, C3-8 cycloalkyl, C1-6 alkyl, C1-4 alkoxy, and trifluoromethyl; R7 is selected from the group consisting of cyano and cyanomethyl; R8, each time taken, is independently selected from the group consisting of hydrogen, cyano, halo, C1-4 alkyl, C1-4 alkoxy, and trifluoromethyl; R9 is selected from the group consisting of hydrogen, C1-6 alkyl optionally substituted with 1 to 3 fluoro, and C3-8 cycloalkyl. |
