Thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions

摘要

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.

主权项

1. A method of localizing thermal damage to a targeted component of a skin tissue with a surfactant composition, comprising:
topically applying a composition comprising a surfactant and nanoparticles to a skin surface of a skin tissue; wherein the skin tissue comprises a targeted component of the skin tissue and a non-targeted component of the skin tissue, wherein the nanoparticles have at least one peak absorption wavelength selected from the group consisting of: 755 nm, 800-810 nm, and 1064 nm, wherein the nanoparticles are unassembled, wherein the nanoparticles have a concentration of 109 to 1016 particles per ml of the composition, wherein the nanoparticles comprise a conductive metal portion comprising at least one of gold, silver, and platinum, wherein the nanoparticles comprise a coating that coats the conductive metal portion; targeting a pilosebaceous unit by redistributing a portion of the composition of nanoparticles from the non-targeted component of the skin tissue to the targeted component of the skin tissue while a remaining portion of the composition is left on the non-targeted component of the skin tissue; removing the remaining portion of the composition from the non-targeted component of the non-targeted component of the skin tissue; and irradiating the composition of nanoparticles with an energy source to induce a surface plasmon in said nanoparticles, thereby localizing thermal damage to said targeted component of the skin tissue.