Activated nitric oxide donors and methods of making and using thereof

摘要

Described herein are compositions useful in anticancer treatment. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment are also described herein.

主权项

1. A method for treating cancer comprising administering to a subject a micelle composition comprising:
(a) O2-(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) or the pharmaceutically acceptable salt or ester thereof; and (b) a poloxamer having the formula
HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is from 50 to 80 and b is from 10 to 25, and wherein the cancer is leukemia.