发明名称 |
A METHOD OF IDENTIFYING A NEONATE AT RISK OF HAVING OR DEVELOPING HYPOXIC-ISCHAEMIC ENCEPHALOPATHY (HIE) |
摘要 |
A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE. |
申请公布号 |
US2016348175(A1) |
申请公布日期 |
2016.12.01 |
申请号 |
US201515112036 |
申请日期 |
2015.01.16 |
申请人 |
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK |
发明人 |
Murray Deirdre;Looney Ann Marie;Boylan Geraldine;Cryan John |
分类号 |
C12Q1/68;A61F7/00 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method of identifying risk of HIE in a distressed neonate, comprising a step of assaying a biological sample obtained from the distressed neonate, mother of the neonate, or placenta or umbilical cord, for an abundance of miR-374a in the sample, wherein a reduced abundance of miR-374a in the sample relative to a reference abundance of miR-374a is indicative of a risk of HIE in the distressed neonate. |
地址 |
Cork IE |