发明名称 |
Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function |
摘要 |
The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.
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申请公布号 |
US7741271(B2) |
申请公布日期 |
2010.06.22 |
申请号 |
US20050080091 |
申请日期 |
2005.03.14 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;BETH ISRAEL DEACONESS MEDICAL CENTER, INC. |
发明人 |
KUCHROO VIJAY K.;CHAKRAVARTI SUMONE;STROM TERRY;ZHENG XIN XIAO;MEYERS JENNIFER |
分类号 |
A61K38/00;A61K38/17;A61K39/395;A61K45/00;A61K47/00;A61K48/00;C07K14/705;C07K16/28;C12N15/11;G01N33/576;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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