PREPARATION OF N-(L-ALKOXYALKYL)FORMAMIDE AND ALKYLIDENE BISFORMAMIDES USING AMINE NEUTRALIZED ION EXCHANGE RESINS

摘要

This invention relates to an improved process for the formation of N-(l-alkoxyalkyl)amides with coproduction of alkylidene bisamides. The N-(l-alkoxyalkyl)formamides of this invention are prepared by reacting formamide with an acetal or hemiacetal carboxylate ester represented by the formulas below in the presence of a solid acid ion exchange resin wherein the acid groups have been neutralized with an amine compound having a pKa (as the protonated amine in water) from about 4 to 9. The hemiacetal ester is represented by formula I and the acetal is represented by formula II. <IMAGE> I <IMAGE> II In the above formulas, R is C1-C8 alkyl, aralkyl or aryl; R1 and R2 are C1-C8 alkyl, or aryl; and R3 is secondary or tertiary alkyl having from 3-8 carbon atoms.