发明名称 |
PARTICLES FOR NMR IMAGING AND METHOD OF MANUFACTURE |
摘要 |
Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three-dimentional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or interwined with a non-ionic surfactant to produce a protective three-dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood ciculation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments. |
申请公布号 |
WO9404197(A1) |
申请公布日期 |
1994.03.03 |
申请号 |
WO1993EP02046 |
申请日期 |
1993.07.30 |
申请人 |
SINTETICA SA |
发明人 |
TOURNIER, HERVE;HYACINTHE, ROLAND;SCHNEIDER, MICHEL |
分类号 |
A61K9/127;A61B5/055;A61K;A61K49/00;A61K49/18;(IPC1-7):A61K49/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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