摘要 |
PURPOSE:To obtain a suppressor for arteriosclerotic intravascular membrane hyperplasia, containing a specific pyridine derivative and useful for treating cardiac infarction, angina pectoris and arteriosclerosis. CONSTITUTION:The medicine contains a compound expressed by formula I [ring X is (substituted)phenyl or 5-to 6-membered ring heteroaryl; R<1> and R<2> are H, 1-8C alkyl, 3-7C cycloalkyl, 1-3C alkoxy, CF3, OCF3, F, Cl, Br, phenyl, phenoxy, benzyloxy, OH, etc.; R<3> is H, 1-8C alkyl, 2-6C alkenyl, formula II (R<7> is H, alkyl, alkoxy, alkylthio, F, Cl, Br, OH, etc.), etc.; Y is CH2, CH2CH2, CH=CH, CH2-CH=CH, etc.; Z is Q-CH2-W-CH2-CO2R<12>, formula III, IV, etc.; Q is CO, CH(OH), etc.; W is CO, C(R<11>)(OH), etc.; R<11> is H or alkyl; R<12> is H, Na, K, etc.], e.g. (E)-3,5-dihydroxy-7-[4'-(4''-fluorophenyl)-2'-cyclopropyl- quinolin-3'-yl]hept-6-enoic acid.
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