Inhibitors of farnesyl protein transferase

摘要

Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, and inhibition of cholesterol biosynthesis, are effected by compounds of the formula their enantiomers, diastereomers, and pharmaceutically acceptable salts, prodrugs, and solvates, wherein: x is -ONR1C(O)-, -N(OR1)C(O)-, -NR1C(O)-, -C(O)NR1-, -NR1S(O2)-, -C(O)O-, -OC(O)-, -C(O)-, -O-, -NR1- or -(S)q-; Y is -CO2R2, -SO3R2 or -P(O) (OR2) (R3); R is alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkenylene or aryl; R3 is -(O)tR4; R1, R2 and R4 are each independently hydrogen, alkyl, aryl or aralkyl; m and n are each independently 0 or an integer from 1 to 5; p and t are each independently 0 or 1; and q is an integer from 1 to 2.