发明名称 |
AMINOCYCLOHEXANE DERIVATIVES AS 5-HT RECEPTOR AGONISTS |
摘要 |
A class of substituted aminocyclohexane derivatives are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1D.alpha. receptor subtype relative to the 5-HT1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.
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申请公布号 |
CA2258051(A1) |
申请公布日期 |
1998.01.29 |
申请号 |
CA19972258051 |
申请日期 |
1997.07.15 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
SHOWELL, GRAHAM ANDREW;MACLEOD, ANGUS MURRAY;STREET, LESLIE JOSEPH |
分类号 |
C07D209/14;C07D521/00;(IPC1-7):C07D403/04;C07D471/04;C07D495/04;C07D498/04;C07D513/04;C07D491/048;C07D403/06;C07D401/14;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;A61K31/41;A61K31/435;A61K31/495;A61K31/535 |
主分类号 |
C07D209/14 |
代理机构 |
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主权项 |
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地址 |
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