MODULATION OF NEUROTRANSMITTER ACTIVITY IN NEURONS

摘要

The present invention relates generally to methods, devices and compositions for treating mental, neurological, and cognitive diseases related to deficiencies in the biosynthesis and/or metabolism of neurotransmitters, wherein the neurotransmitter is acetylcholine, nitric oxide, histamine, norepinephrine, a bioactive amine, an amino acid or a neuropeptide, veratridine, curare, tetrodotoxin, f lunarizine, calsicludine, and omega -cono toxin; wherein the bioactive amine is selected from the group consisting of dopamine, epinephrine, norepinephrine, serotonin; wherein the amino acid is selected from the group consisting of glutamate, glycine and gamma- aminobutyric acid (GABA) ; the neuropeptide is selected from the group consisting of enkephalins, dynorphins and substance P and the psychological disorder is selected from the group consisting of addiction, substance abuse, autism, dyslexia, obsessive- compulsive disorder, generalized anxiety disorder, post- traumatic stress disorder, panic attacks, social phobia, major depression, bipolar disorder and schizophrenia, tardive dyskinesia, Huntington's disease, and Parkinson's disease.