发明名称 |
CASPASE-2 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS. |
摘要 |
<p>The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone : 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Vanilyl-L-Alaninyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester (SEQ1) and derivatives thereof, SEQ 1 corresponding to formulae (Ia) or (Ib). Application of said inhibitors for preventing and treating diseases involving caspase-2.</p> |
申请公布号 |
MXPA06012391(A) |
申请公布日期 |
2007.01.31 |
申请号 |
MX2006PA12391 |
申请日期 |
2005.05.02 |
申请人 |
THERAPTOSIS S.A. |
发明人 |
DAVID CHAUVIER;ETIENNE JACOTOT;RICHARD CASIMIR;DOMINIQUE REBOUILLAT |
分类号 |
A61K38/57;A61P25/28;C07K7/00;C07K14/47;C07K14/81 |
主分类号 |
A61K38/57 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|