AUTOMATIC PARAMETER SELECTION AND THERAPY TIMING FOR INCREASING EFFICACY IN THE RESPONSIVE NEURODEVICE THERAPIES OF BRAIN DISEASE AND INJURY

摘要

An automatic fully responsive neurotherapy system and method are provided that recognizes and automatically selects efficacious therapy parameters, to finely manipulate the on-off timing of therapy delivery aimed at improving efficacy over the entire lifespan of the device. The system incorporates auto tuning of the character, dose, and timing of neurostimulation across patients, and on-the-fly, on a patient-specific, event-by-event basis. "Pre-" and "post-therapy effectivity" features are derived from biological signals and seizure detection subsystems, and a self-organizing "therapy rulebase" is developed from the storage/archiving subsystems to make sense of these "effectivity" features, and subsequently command their trajectories in directions of clinical improvement.