Insulin on board compensation for a closed-loop insulin infusion system

摘要

An electronic controller for an insulin infusion device includes a processor architecture and at least one memory element. The memory element stores executable instructions that, when executed by the processor architecture, provide an insulin on board (IOB) compensation module to estimate a current IOB value that indicates an amount of active insulin in the body of the user, calculate an IOB rate based at least in part on the estimated current IOB value, determine an adjusted insulin infusion rate based at least in part on the calculated IOB rate and an uncompensated insulin infusion rate, select a final insulin infusion rate for the device, and provide the selected final insulin infusion rate to regulate delivery of insulin by the device.

主权项

1. An electronic insulin infusion device comprising:
an insulin reservoir for insulin to be delivered from the insulin infusion device to a body of a user; a processor architecture comprising at least one processor device; and at least one memory element associated with the processor architecture, the at least one memory element storing processor-executable instructions that, when executed by the processor architecture, perform a method of controlling closed-loop delivery of insulin from the insulin reservoir to the body of the user, the method comprising:
computing a current insulin on board (IOB) value that indicates an amount of active insulin in the body of the user;calculating an IOB rate based at least in part on the computed IOB value, wherein the IOB rate represents an amount of active insulin accumulated from manual boluses in the body of the user per unit of time;determining an adjusted insulin infusion rate based at least in part on the calculated IOB rate and an uncompensated insulin infusion rate;selecting a final insulin infusion rate for the insulin infusion device, wherein the selecting selects either the determined adjusted insulin infusion rate, the uncompensated insulin infusion rate, or a current basal rate as the final insulin infusion rate, wherein selecting the final insulin infusion rate is in accordance with either expression FinalRate(n)=max(Basal; AdjustedRate(n)) when PIDRate>Basal, or expression FinalRate(n)=PIDRate(n) when PIDRate Basal, wherein:FinalRate(n) is the selected final insulin infusion rate;Basal is the current basal rate;AdjustedRate(n) is the determined adjusted insulin infusion rate; andPIDRate(n) is the uncompensated insulin infusion rate; andoperating the insulin infusion device in a closed-loop mode to continuously deliver insulin from the insulin reservoir to the body of the user in accordance with the final insulin infusion rate that is selected, wherein the final insulin infusion rate represents an amount of insulin to be delivered per unit of time.