Compositions and methods of treating retinal disease

摘要

Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.

主权项

1. A method of treating macular degeneration and other forms of retinal disease mediated by accumulation of A2E and/or lipofuscin in a subject, the method comprising administering to the subject in need thereof a composition comprising a compound of formula IIIa: or a pharmaceutically acceptable salt thereof, wherein: A is; B is a halogen atom, hydroxyl, carbamoyl, aryl or amino; p is 0, 1, 2, or 3; D is unbranched lower alkyl; L is a single bond or CH2; and X, Y, and Z are each, independently, N, NH, O, S, CB, CH, or absent, such that at least one of X, Y, and Z is N or NH; wherein X, Y, and Z and the carbon atoms to which they are attached form a 5- or 6-membered optionally substituted heterocyclic ring.