High capacity diketopiperazine microparticles and methods

摘要

Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.

主权项

1. A composition comprising a plurality of diketopiperazine microparticles and a drug or an active agent; wherein each of the diketopiperazine microparticles comprises a plurality of structural domains, each structural domain comprising a nucleus surrounded by layers of a porous crystalline material, and said diketopiperazine microparticles have a mass-weighted average particle size of about 33,000 to about 216,000 voxels measured by X-ray tomography for particle size measuring about 0.5 μm to about 4 μm in geometric diameter.