| 摘要 |
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, chemical-pharmaceutical and cosmetic industry, namely to method of producing liposomal form ubiquinol (reduced Coenzyme Q), involving preparation of solution, containing mixture of phospholipid and sterol in weight ratio of 1:0.1-2 respectively, ubiquinol with weight ratio of ubiquinol to mixture of phospholipid and sterol equal to 1:1-4, respectively, and co-solvent in form of nonionic surfactant in ethanol, dispersion of obtained solution, containing lipid fraction, in aqueous medium containing cryoprotectant to obtain suspension of lipid vesicles with ubiqinol in them, homogenization of suspension of lipid vesicles and separation of liposomes with size no more than 220 nm with ubiquinol included therein, as well as to liposomal pharmaceutical and cosmetic compositions including liposomal form of ubiquinol obtained using said method.EFFECT: group of inventions provides higher bioavailability of coenzyme Q, higher capture factor and stability of retention of coenzyme Qin liposomes.24 cl, 12 ex, 1 tbl, 1 dwg |
