| 摘要 |
FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, specifically to immunology, and can be used for preparing immunogenic composition. Multivalent immunogenic composition contains 15 various polysaccharide-protein conjugates, as well as physiologically acceptable base. Each of polysaccharide-protein conjugates contains capsular polysaccharide, obtained from different serotypes of Streptococcus pneumoniae, conjugated with protein CRM, wherein capsular polysaccharides are obtained from serotypes 1, 2, 3, 4, 5, 6A, 6B, 7F, 9N, 9V, 14, 18C, 19A, 19F and 23F. Group of inventions also relates to pharmaceutical composition made in form of single dose of 0.5 ml, containing: 2 mcg of each saccharide, except 6B, which is in amount of 4 mcg; approximately 34 mcg of carrier-protein CRM; adjuvant based on 0.125 mg of elementary aluminium (0.5 mg of aluminium phosphate) and buffer based on sodium chloride and sodium succinate as filler. Immunogenic composition made in form of vaccine, containing aluminium adjuvant, allows to increase range of application on pneumococcal diseases.EFFECT: use of one type of carrier-protein conjugated with encapsulated polysaccharides in multivalent vaccine, allows avoiding possible immune interference.7 cl, 4 ex, 15 dwg, 3 tbl |
