发明名称 SUBSTITUTED BENZYLOXYCARBONYL GUANIDINES, METHOD OF THEIR PRODUCING, THEIR USE AND DRUGS CONTAINING THEM
摘要 Disclosed are compounds of formula (I), wherein the symbols R1, R2 and R3 has the meaning defined in disclosure, symbols R4 and R5 are always H, (C1-C6)alkyl, fluorine, chlorine, hydroxyl, (C1-C3)alkoxyl, aminogroup, optionally (C1-C3)-alkylsubstituted or (C1-C4)-perfluorinealkyl group, symbols R6 and R7 are always H or (C1-C4)-alkyl and X is H, imine-group or (C1-C4)-alkylimine-group, as well as their pharmaceutically acceptable salts, process for production of these compounds and medicaments containing them. These compound are effective inhibitors of the cell interchangeable system Na+/H+, hence they are suitable for treatment of diseases related to the increased interchange Na+/H+.
申请公布号 SK62996(A3) 申请公布日期 1996.12.04
申请号 SK19960000629 申请日期 1996.05.15
申请人 HOECHST AG 发明人 KLEEMANN HEINZ-WERNER;BRENDEL JOACHIM;SCHWARK JAN-ROBERT;WEICHERT ANDREAS;LANG HANS-JOCHEN;ALBUS UDO;SCHOLZ WOLFGANG
分类号 C07D215/20;A61K9/06;A61K9/10;A61K31/155;A61K31/17;A61K31/175;A61K31/18;A61K31/27;A61K31/275;A61K31/44;A61K31/4406;A61K31/4418;A61K31/47;A61K31/475;A61K35/00;A61P1/16;A61P3/08;A61P9/00;A61P9/06;A61P9/08;A61P9/10;A61P13/02;A61P15/00;A61P35/00;A61P43/00;C07C279/10;C07C279/24;C07C317/22;C07C317/32;C07C317/46;C07D213/30;C07D215/14;G01N33/574;G01N33/94;(IPC1-7):C07C279/10;C07C279/00;C07C277/08;G01N33/53 主分类号 C07D215/20
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