| 发明名称 |
VERFAHREN ZUR HERSTELLUNG VON E-1-[4'-(2-DIMETHYLAMINOETHOXY)-PHENYL]-1-(3'HYDROXYPHENYL)-2-PHENYL-1-BUTEN |
| 摘要 |
<p>PCT No. PCT/EP94/00001 Sec. 371 Date Sep. 23, 1996 Sec. 102(e) Date Sep. 23, 1996 PCT Filed Jan. 3, 1994 PCT Pub. No. WO95/18786 PCT Pub. Date Jul. 13, 1995The present invention relates to methods for the production of E-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene of formula (I) which comprises heating the compound of formula (II) in the presence of an organic solvent and HCl gas and cooling the reaction to obtain the compound of formula (IIIa), and then heating the isolated compound of formula (IIIa) in the presence of sulfuric acid or hydrochloric acid to obtain the compound according to formula (I). <IMAGE> Formula (I) <IMAGE> Formula (II) <IMAGE>e protecting group</p> |
| 申请公布号 |
DE69409835(T2) |
申请公布日期 |
1998.10.01 |
| 申请号 |
DE1994609835T |
申请日期 |
1994.01.03 |
| 申请人 |
KLINGE PHARMA GMBH, 81673 MUENCHEN, DE |
发明人 |
GRILL, HELMUT, D-85591 VATERSTETTEN, DE;WOSCHINA, AXEL, D-85586 POING, DE |
| 分类号 |
C07C213/08;C07C;C07C213/00;C07C215/46;C07C217/18;C07C217/20;C07C217/54;(IPC1-7):C07C213/08 |
主分类号 |
C07C213/08 |
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