发明名称 |
METHODS AND COMPOSITIONS FOR ELICITING AN IMMUNE RESPONSE TO A TELOMERASE ANTIGEN |
摘要 |
The invention provides a method of activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context of a MHC class I or MHC class II molecule. The DC may be pulsed with a TRT polypeptide or may comprise a recombinant polynucleotide encoding a TRT such as hTRT. The invention also provides DCs comprising a recombinant TRT polynucleotide. The methods and compositions of the invention are used in prevention and treatment of cancers and other cell proliferation diseases or conditions. |
申请公布号 |
WO9950392(A1) |
申请公布日期 |
1999.10.07 |
申请号 |
WO1999US06898 |
申请日期 |
1999.03.30 |
申请人 |
GERON CORPORATION;GAETA, FEDERICO, C., A. |
发明人 |
GAETA, FEDERICO, C., A. |
分类号 |
C12N15/09;A61K35/14;A61K38/43;A61K39/00;A61P35/00;A61P37/00;C12N5/06;C12N5/08;C12N5/10;C12N9/12;(IPC1-7):C12N5/06;C12N9/00;C12N5/22 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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